Sophos Antivirus is an application that protects your computer from unknown threats such as spyware, malware, and ransomware. It is supported on both the Mac and Windows operating systems. If your Mac displays an error message like “Sophos Antivirus Error Not Running,” or you could not run the Sophos antivirus, then it might be due to the obsolete version of the antivirus or compatibility issues. To resolve this problem, follow the below-mentioned troubleshooting steps.